Int. Jr. Bioinformatic and Biological Sci. : v.2 n.3 and 4, p. 145-152. Dec. 2014

DOI No. 10.5958/2321-7111.2014.00012.2 3

Angiotensin receptors: their pharmacological aspects

and side effects vis-à-vis receptor blocker drugs

Reeta Singh Gaur 1 *, Anjali Verma 2 and Satendra Singh 3

1 TMU University, Moradabad, Uttar Pradesh-244001, India.

2 Department of Physiology, TMU University, Moradabad, Uttar Pradesh-244001, India.

3 Department of Computational Biology and Bioinformatics, JSBB, Sam Higginbottom,

Institute of Agriculture, Technology and Sciences, Allahabad-211007, India

*Corresponding author: deolreeta@gmail.com

ABSTRACT

Receptors are the protein molecules embedded in plasma membrane, cytoplasm

or nucleus. Receptors received its chemical signals originating from the cells.

Through binding to receptors these signals directed cell to produce its action. There

are different psychological actions produced by Angiotensin-II such as increase in

extracellular volume, peripheral vascular resistance and blood pressure. It is also

involved in regulation of cell growth and differentiation. Angiotensin-II Receptor

is of two types,AT-I andAT-II. Most of the functions of angiotensin-II are regulated

by AT-I. Physiological role of AT-II are not known. Various vital organs of the

body like Heart, lungs, kidney, adrenal cortex and brain are rich in AT-I Receptor.

Those drugs which block the action of AT-1 on blood vessels and Heart are called

as Angiotensin Receptor Blocker (ARBs). There are different ARBs available in

the market which are well tolerated and having fewer side effects. ARBs biding

affinity towards the receptors is like as condensatran > ibesartan> valsartan>

telmisartan> tasosartan> losartan >eprosartan. The main severe side effect shows

by ARBs is swelling of tissues, liver and kidney failure, allergic reactions.

Keywords : Membrane, cytoplasm, psychological.

All physiological actions of angiotensin-II in cardiovascular, hepatic renal,

endocrine and other target cells are shown by Angiotensin AT-1 receptor. All

these activity responsible for regulation of different body function like hormone

secretions, arterial blood pressure, electrolyte and water balance, thirst, and renal

function.AT-1 receptor is from G-Protein Coupled receptor family .After binding to

the AT-1 receptor, Angiotensin-II shows its physiological reactions (De Gasparo et

al ., 2000). There are different cellular response of AT-1 receptor including smooth

muscles contraction, proliferation, aldosterone secreation, neurosecreation, ion

transport, steriodogenesis, and cell growth. The AT ₁ receptor is coupled with well