Angiotensin receptors: their pharmacological aspects and side effects
When AT-I receptor blocks by ARBs it leads to lowering of blood pressure
because of Antagonizing angiotensin-II. Which further induced vasoconstriction,
aldosterone release, catecholamine, arginine, vasopressin release, water intake,
and hypertrophic response and other reactions?
please send a fuoll image in corel or jpeg file
Figure -2 Physiological Regulations of Electrilyte Balance, Plasma Volume and Blood
Pressure by the Renin Angiotensin System
( Source -Essential of Medical Pharmacology by K.D.Tripathi)
Different available ARBs and their side effects-
ARBs include following drugs-
ARBs are the first choice for treatment for most people who having blood
pressure. Because they are well tolerated with less side effect in comparison to
ACE inhibitors because they do not affects bradykinin level of body. But ARBs
are recommended to people those people who are less then 55yrs of age. But
contraindicate in women who are pregnant, breastfeeding or planning a pregnancy.
The most common side effects ofARBs are like dizziness, headache, cold or flu etc.
The side effects of cough found less in patient treated with ARBs as comparison to
patients treated with ACE inhibitors. And the rare side effects are like swelling of
lips, tongue or face .Some time ARBs causes increase in Potassium level of body
and changes in kidney function.
Condensartan
Condensartan is prolonging effective angiotensin-II receptor antagonist with best
angiotensin-II antagonist activity. AT-1 binding affinity in rabbit aorta is 80 times
greater than losartan. Elimination takes place through Kidney (Approx.60%) and
Bile (Approx.40%).General side effects of condensartan are runny or stuffy nose,
International Journal of Bioinformatics and Biological Sciences : v.2 n.3&4. Dec. 2014
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