Gaur et al.

sore throat, cough, back pain, joint pain, stomach pain, diarrhea, headache, and

dizziness. And others side effects of condensartan like chest pain, swelling in

hands or feet, slow heart rate, weak pulse rate and tingly feeling are serious to take.

Eprosartan

Eprosartan is categorized in latest angiotensin-II receptor antagonist. Half life of

Eprosartan is short and absorption is reduces if taken with food. Metabolism of

Eprosartan takes place in liver and converted in to glucuronide and then excreted

through urine. Acute liver injury caused by ARBs and taking of alcohol can

have an additive effect. They can rarely cause skeletal muscle breakdown which

aggravated the kidney failure.

Ibesartan

Ibesartan is long effective AT-1 receptor antagonist as compare to losartan and

valsartan. It is having high binding affinity towards theAT-1 receptor but shows no

affinity towardsAT-2 receptors. It is eliminated through kidney and bile. Generally

reported side effects is gastrointestinal side effects like diarrhea ,dyspepsia

,abdominal pain, nausea, vomiting, and constipation, fatigue, headache, chest

pain muscles weakness sexual dysfunction, alteration in libido. Allergic reactions

reported very rarely by Ibesartan.

Losartan

The first oral active AT-1 receptor blocker is Losartan. It shows negative side

effects in to the body. Flu, cramping of muscle, back pain, stomach pain, diarrhea

and insomnia are mild side effects. Cramping of muscle, back pain and weakness

in combination with fever, vomiting, dark color of urine are dangerous side effects

of Losartan.

Olmesartan

Olmesartan is a specified angiotensin-II type 1 antagonist which can be use alone

as well as in Combination with other antihypertensive drugs. Its bioavailability is

unaffected by food. Dizziness is a common side effect of it but skin rashes, itching,

swelling oh head or neck, difficulty in breathing or swallowing and decreased

amount of urine produced are serious side effects produced by Olmesartan

Telmisartan

It is the long acting angiotensin-II receptor antagonist. Excretion takes place

through feces(98%).Upper respiratory tract infection, back pain, inflammation of

150

International Journal of Bioinformatics and Biological Sciences : v.2 n.3&4. Dec. 2014