Angiotensin receptors: their pharmacological aspects and side effects

sinuses, dry mouth, migraine and gout are the common side effects reported and

skin rashes, swelling of head or neck reported are serious side effects.

Valsartan

It is a potent angiotensin-I antagonist, which is excreted by kidney and bile. Its

absorption decreased (approx 40%) by food. Most common side effects are like

fatigue, stomach pain, Infection with cold, flu, hair loss, dizziness, cough and

anxiety but difficulty in breathing or swallowing and decrease amount of urine

output are serious conditions.

Future Development

In the treatment of different disease related to cardiac activity like hypertension,

congestive heart Failure and renal disease, angiotensin receptor blockers

combinations and ACE inhibitors are mostly preferred to block the Rennin

Angiotensin System. Combination of these drugs can improve blockade of Rennin

Angiotensin System ( Azizi M et. al., 1995 ).There are a lot of studies done to assess

the effect of combination of drugs and their side effects elated to treatments. Some

contradictory result is available on the subject of the dosing of AT-1 receptor and

ACE inhibitors.

Conclusion

Today disease related to cardiac problem is major issue for medical practitioners.

There is a lot of studies are present for different angiotensin receptor blockers

.Different studies shows thatARBs drugs are equally effective likeACE inhibitors,

beta blockers, calcium channel blocker in the treatment of mild to moderate

hypertensive patients. ARBs are reported with lesser side effects as compare to

other class of drugs.And they are well tolerated also.ARBs show strong activity in

the management of Hypertension, Heart failure, or Renal disease. Rarely patients

are reported with major side effects Damage of organ and reduced cardiovascular

morbidity and mortality prevented by ARBs.

References

Azizi M, Chatellier G, Guyene TT, et al. 1995. Additive effects of combined angiotensin-

converting enzyme inhibition and angiotensin II antagonism on blood pressure and

renin release in sodium-depleted normotensives. Circulation . 92 : 825–834

Bumier M. 2001. Angiotensin II type 1 receptor blockers. Circulation . 103 : 904-912.

Burnier M, Brunner HR. 2000. Angiotensin II receptor antagonists. Lancet. 355 :637–645.

De Gasparo M, Catt KJ, Inagami T, Wright JW, Unger T. 2000. International union of

pharmacology. XXIII. The angiotensin II receptors. Pharmacol. Rev. 52 (3): 415–72.

International Journal of Bioinformatics and Biological Sciences : v.2 n.3&4. Dec. 2014

151