Lal et al.

There is a enormous potential for the application of metals in medicine and the

selection of metal ions offer the possibility for the discovery of metallodrugs

with novel mechanism of action. Metals containing compounds may offer certain

advantages over pure organic compound in drug therapy i.e. the metal complexes

may act as a pro-drug (Yu et al.,2003). Bismuth compounds have attracted

considerable interest owing to their biological and medical utility, they have been

utilized for more than two centuries in the treatment of gastrointestinal disorders

such as dyspepsia, diarrhea and peptic ulcer. Bismuth salts such as colloidal

bismuth sub-citrate (CBS), bismuth sub –salicylate (BSS), and ranitidine bismuth

citrate (RBC) are common agents used for Helicobacter pyroli eradication therapy

and therefore these compounds as antimicrobial . It is known that metals are able

to generate reactive oxygen species (ROS) which easily explain the treatment

of cancer. In search of antiproliferative studies, a variety of organobismuth

compounds have been synthesised (Luan et al. , 2011) and tested in vitro for their

antitumor activity along with their antimicrobial activity. Despite the long history

of organobismuth as bio-medicinal agents the mechanism of action is not fully

understood, which is an important issue for us to know that how organobismuth

compound act against microorganism and tumours (Tripathi et al. , 2011). The

present communication reveals the antitumor activity of some organobismuth

compounds.

Materials and Methods

Homology modeling

The first step towards succesful in silico drug designing is 3-D structure modelling.

The FASTA sequence of the target 2VNA (Structure of Human Zinc-Binding

Alcohol Dehydrogenase 1 (ZADH1) protein was obtained from protein database

of NCBI.

Table 1. Showing softwares and online servers used during the study

Softwares and

S.N.

Description

Online Servers

The NCBI houses a series of databases relevant to

1.

NCBI

biotechnology and biomedicine

The Protein Data Bank (PDB) archive is the single

worldwide repository of information about the 3D

2.

PDB

structures of large biological molecules, including proteins

and nucleic acids.

3.

Pubchem

PUBCHEM structure editor helps in structure drawing.

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International Journal of Bioinformatics and Biological Sciences : v.2 n.3&4. Dec. 2014