Journal of Animal Research: v.5 n.1, p. 95-97. April. 2015
DOI Number: 10.5958/2277-940X.2015.00015.7
Comparative Efficacy of different Antimicrobials Used in the Treatment of
Colibacillotic Calves
Riyaz Ahmed Bhat*, Ghulam Nabi Sheikh and Ovais Shabir Shah
Division of Veterinary Medicine, Faculty of Veterinary Sciences & Animal Husbandry, SKUAST-K, Srinagar, J & K, INDIA
*Corresponding author: RA Bhat; Email: koolriya22@gmail.com
Received: 28 January, 2015
Accepted: 01 March, 2015
ABSTRACT
Colibacillosis of newborn calves is characterised by rapid onset, watery white or yellowish diarrhoea and high mortality. In the
present therapeutic study the efficacy of four highly sensitive in-vitro drugs viz., ciprofloxacin, gentamicin, neomycin and co-
trimoxazole was evaluated. Ciprofloxacin at the dose rate of 4mg/kg body weight was found 100 per cent effective, gentamicin
at the dose rate of 4mg/kg body weight was found 83.33 per cent effective where as neomycin @10mg/kg body weight and co-
trimoxazole @ 25 mg/kg body weight were found 66.67 per cent effective in this study. Treatment regimen used in four different
groups of clinical cases of colibacillosis indicated ciprofloxacin being most effective drug followed by gentamicin, neomycin
and co-trimoxazole which was comparable with in-vitro studies.
Keywords : calves, colibacillosis, diarrhoea, treatment
Colibacillosis is one of the important diseases in new born
into 5 different groups with 6 animals in each group and
calves, caused by pathogenic serotypes of Escherichia coli
one group comprising of apparently six healthy animals
(Carlton, 1992) and characterized by prostration, profuse
kept as healthy control (Table 1). Four drug regimens
diarrhoea, emaciation and septicemia. Enterotoxigenic E.
were used in four groups which contained four different
coli causing colibacillosis is the major cause of calf scours
antibacterials, oral rehydration therapy and other
leading to huge economic loss (Badiei, 2011) and may
supportive therapy. Only those antibacterials were used
cause mortality between 5-25 per cent (Basoglu, 1992) or
which showed moderate to high sensitivity pattern, were
even as high as 54.58 per cent (Khan and Khan, 1997).
readily available and economically feasible. Calves of the
Treatment of the disease with antimicrobials remains
group 2 were mentained as infected control wherein no
the exclusive method for reducing economic loss along
treatment was given.
with supportive treatment. Treatment of the disease with
antimicrobials remains the exclusive method for reducing
RESULTS AND DISCUSSION
economic losses along with supportive therapy. Different
antibiotics are being used by vaterinarians with variable
Therapeutic efficacy of different drugs was determined
results. Therefore, this study, reports the comparative
through clinical evaluation of different parameters on daily
efficacy of different antimicrobials in the treatment of
basis (Table 2). The efficacy of the drugs was assessed
colibacillotic calves.
on the basis of clinical recovery and time taken for the
disappearance of the clinical symptoms. The calves of
group 2 (infected control), recovered after the trial period
MATERIALS AND METHODS
and remained weak. Group 6 was given ciprofloxacin
Inthepresentstudy,30calvesclinicallyandbacterialogically
@4mg/kg body weight orally (250 mg tab-1/3 rd bid) for
diagnosed to be affected with colibacillosis were divided
five days and it proved to be the most effective drugs