Comparative Efficacy of different Antimicrobials
per cent efficacious in this study. There was marked
REFERENCES
improvement in clinical signs in four cases by day six
Basoglu, A., Turgut, K., Maden, M. and Kaya, O. 1992. Studies
with delay in recovery in two cases even after 144 hour
on the importance of crypotosporidium in diarrhoeic calves.
post treatment. This drug helps in restoration of disturbed
Hayvancilik Arastrima-Dergisi, 2(1): 40-41.
haematobiochemical parameters towards normalcy by day
Blood, D.C. and Radostits, O. M. 1989. Veterinary Medicine, 7 th
six. This drug given orally is currently labeled in United
Edition, ELBS, Oxford.
States for the treatment of calf diarrhoea (Constable, 2004).
Carlton, L.G. 1992. Escherichia coli cytotoxins and enterotoxins.
The infected calves of group 3 were given co-trimoxazole
Canadian J. Microbio., 38: 734-746.
at the dose rate of 25 mg/kg body weight orally (1/5 th
Choudhary, M. and Das, S.D. 2003. Incidence of drug resistance
bolus), showed 66.67 per cent efficacy in this study. There
in E. coli strains in west Bengal. Indian Vet. J ., 74: 422-23.
was marked improvement in clinical signs in four cases
Constable, P.D. 2004. Antimicrobial Use in the Treatment of
by day six with delay in recovery in two cases even after
Calf Diarrhoea. J Vet Intern Med., 18 :8-17.
144 hour post treatment. This drug helps in restoration
Dubey, C.K. and Rao, K.N.P. 1991. Some observations
of disturbed haematobiochemical parameters towards
on therapeutic applicability of norfloxacin in enteric
normalcy by day six. Oral co-trimoxazole was also tried
colibacillosis. Indian Vet. J., 68: 761-764.
by Dubey and Rao (1991). Though endowed with a wide
DuPont, H.L., Reves, R.R, Galindo, E., Sullivan, P.S., Wood,
range of anti-bacterial activity, sulphonamides are not very
L.V. and Mendiola, J.G. 1982. Treatment of traveller’s
effective against E. coli . Trimethoprim is, however, highly
diarrhea with trimethoprin-sulphamethoxazole and with
effective against both Gram positive and Gram negative
trimethoprim alone. New England J. Med ., 307: 841-844.
bacteria. Sulphonamide-trimethoprim combination is
Fernandes, C.E., Roy, K., Shukla, P.C. and Rap, M.L.V. 2009.
claimed to possess drug potentiating effect (Dupont et al.,
Comparative efficacy of different antibiotics against neonatal
1982; Hill and Pearson, 1988). In the present study in all
calf diarrhoea. Indian J. Vet. Med ., 29(1): 35-36.
the calves clinically suffering from colibacillosis, 400mL
Hill,D.R.andPearson,R.D.1998.Healthadviceforinternational
of electrolyte solution (oral rehydration salt solution) was
travllers. Ann. Int. Med ., 108: 839-852.
given intravenously. Blood et al. (1989) emphasized on
Jones, E.W., Hamm, D. and Bush, L. 1977. Calf diarrhoea: A
the use of balanced oral or parentral electrolyte solution.
brief resume with observations and treatment and prevention.
On the basis of therapeutic trials of different antibacterials
Bovine Pract ., 12: 48-53.
given to the colibacillotic calves in this study, it is
Badiei, K., Pourjafar, M. and Ghane, M. 2011. Fecal E coil F5
recommended that ciprofloxacin, gentamicin, neomycin
(K99) Antigen in Diarrheic Calves of High and Average
and co-trimoxazole should be recommended for the field
Producing Holstein Dairy Cows. Global Vet ., 6(5): 441-446
use.
Khan,A. and Khan, M.Z. 1997. Bacteria isolated in natural cases
of buffalo and bovine neonatal calf diarrhoea, pneumonia and
pnumoenteritis. Vet. Archiv, 67: 575-578.
ACKNOWLEDGEMENTS
Patil, R.M., Karpe, A.G. and Gujar, M.B. 1999. Studies on drug
Authors are thankful to the DRI, FVSc & AH Shuhama,
resistance and virulence of Escherichia coli from diarrheic
SKUAST-K, J & K for providing necessary man power for
calves. Indian J. Comp. Micro. Immuno. Infect. Dis., 20: 29-
31.
sample collection and required lab facilities.
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