Theriogenology Insight: 4(3): 85-90, December, 2014
DOI Number: 10.5958/2277-3371.2014.00737.2
In silico prediction of buffalo (Bubalus
bubalis) pregnancy associated
glycoprotein-1 signaling pathway
Jerome A * , S.K. Singh and S.K. Agarwal
Indian Veterinary Research Institute, Bareilly, UP, 243122, India
*Corresponding author: jerome210982@gmail.com
Abstract
The present study was conducted to predict and analyze signaling pathway of
buffalo pregnancy associated glycoprotein-1 in silico. Various databases viz.
String database, Panther pathways, Biocarta pathways were used for deducing
signaling of buffalo pregnancy associated glycoprotein-1. Analysis reveals buffalo
pregnancy associated glycoprotein-1 exerts their biological function by interacting
with cytokines viz. placenta growth factor and SP1 transcription factor. Placental
growth factor belongs to the vascular endothelial growth factor superfamily.
Vascular endothelial growth factor is mainly involved in cellular proliferation,
migration, differentiation, angiogenesis acting through protein kinase-C signaling
pathway. SP1 transcription factor is mostly involved in mediators of transcription
and signal transduction during cellular process acting through the SMAD factors.
In toto pregnancy associated glycoprotein-1 through these factors may exert
its biological functions of angiogenesis, endothelial cell growth, proliferation,
migration and differentiation enhancing embryonic growth and development. In
conclusion from this study the signaling pathway of buffalo pregnancy associated
glycoprotein-1 (PAG-1) was predicted in silico.
Keywords: Buffalo , Pregnancy associated glycoprotein, Signaling pathway
Introduction
During pregnancy there are varied cascade of cytokines and their interactions to
accomplish their biological functions (Schäfer-Somi, 2003). This involves various