Contents Volume 5 Issue 2

Tuberculosis is one of the major public health challenges globally. Extra pulmonary tuberculosis (EPTB) is defined as an isolated occurrence of TB at the body sites other than lungs. The aim of this study was to see the frequency of isolation of Mycobacterium from different EPTB samples.

Tubercular lymphadenitis (TBLN) is the most common manifestations of extra-pulmonary tuberculosis (EPTB) accounting for 30-40% of cases with multiple discrepancy in diagnosis. Rapid diagnosis and timely initiation of anti-tubercular therapy (ATT) is the key for successful clinical effects. This study was carried out to evaluate multiplex polymerase chain reaction (MPCR) using MTP40, IS6110, 32 kD-alpha antigen encoding gene, and mycobacterial specific genes (rpoB, katG & inhA promoter region), and compare with the conventional methods for rapid diagnosis of TBLN

Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disease characterised by multisystem involvement. Pulmonary manifestation of SLE varies from pleuritis to severe parenchymal involvement as pneumonitis mimiking as acute respiratory distress syndrome (ARDS). Other pulmonary manifestations of SLE include pulmonary artery hypertension, diffuse alveolar haemorrhage, pulmonary embolism, acutely reversible hypoxaemia, and shrinking lung syndrome. We present the case report of a young woman who presented with severe lupus pneumonitis with central nervous system and renal involvement.

Macroglobulinemia refers to the excess production of IgM monoclonal protein that occurs in certain lymphoproliferative disorders and plasma cell dyscrasias. This broad definition includes patients with monoclonal gammopathy of undetermined significance of the IgM type (IgM MGUS), smoldering Waldenström macroglobulinemia (SWM), Waldenström macroglobulinemia (WM), and a number of related disorders in which an IgM monoclonal protein is detected, such as chronic lymphocytic leukemia (CLL), a number of lymphoma variants, and primary (AL) amyloidosis.WM is a diagnosed by demonstrating lymphoplasmacytic lymphoma (LPL) in the bone marrow with an IgM monoclonal gammopathy in the blood. Infiltration of the hematopoietic tissues or the effects of monoclonal IgM in the blood causes the symptoms associated with disorder.

Abdominal lymphadenopathy is regularly encountered clinical entity and planning a management on likely diagnosis may prove disastrous. In the present case, clinical features with CT findings of massive diffuse paraaortic, mesenteric and splenic group of lymph nodes, mass at the head of the pancreas, encasement of the portal vein, gross splenomegaly and ascites added with suggestion from bone marrow biopsy almost clinched the diagnosis in favour of Hodgkin’s disease. Biopsy, however, turned the table topsy-turvy by confirming these lymph nodes to be of tuberculous origin. Histopathology, thus remains a must tool of information to find a correct diagnosis as observed in this case.