The present text book of General and Systemic Veterinary Medicine contains the material in a concise form and it has been compiled by keeping revised curriculum of Veterinary Council of India (VCI) and Minimum Standards of Veterinary Education (MSVE), 2016 guidelines in sight, so that a uniform syllabus can be followed in various veterinary colleges across the country. This book thoroughly covers all the topics of General and Systemic Veterinary Medicine which will be of great use to veterinary undergraduate students of BVSc & AH. In the present text book, many topics are supported with relevant photographs which will help in better understanding of the topics. The topics are written in a concise manner mainly focusing on undergraduate students. Graphical and schematic presentations of pathogenesis of the various diseases have been provided. It will also be helpful for practicing field veterinarians in better understanding the clinical diseases of animals. This textbook has been written following a thorough review of publications from recognized national and international journals, as well as mainstream Veterinary Sciences textbooks. The information from authentic websites is also incorporated. This textbook will be a useful asset to the fourth year BVSc & AH students as well as field veterinarians.